The blog of Xeno, a slightly mad scientist
I started researching oxygen because my adventurous fiancé is having ozone gas injected into her blood as a therapy. The woman knows no fear. I have to admire her faith in alternative therapies, but at the same time, WTH!??!
After some research, I’m concerned about her risk of death from an embolism in the lungs, general oxidative damage to her epithelial cell membranes, potential vasculitis and death by aneurism. I think ozone therapy will age her more quickly from the inside for the same reason meditation ages us slower: 0yxgen rusts us.
Many people promote ozone therapy. I think I now understand why: She felt bad at first, but plans on 10 to 15 treatments after surviving the first one and feeling good for a day. Why?
When the extra oxygen starts rusting you, T-cells are mobilized as the immune system starts to clean up all the damage. At the right concentration you get an increase in the production of interferon and interleukin-2 which launches a cascade of immunological reactions. – link. This is because your body is under attack from the extra oxygen which creates highly reactive free radicals. In addition to other free radicals, the extra oxygen in your blood reacts to quickly form hydrogen peroxide which is an irritant. Your cells have protective barriers, cell membrades made of lipids. Hydrogen peroxide in your blood results in lipid peroxidation where electrons are stolen from the cell membrane damaging the cell and creating more free radicals. This damage constricts your blood vessels and you then get less oxygen and nutrients to your cells, so you get a “high”, like right before you black out from holding your breath.
Another result is the release of neurotransmitters, some of which elevate the mood. If it feels good, it must be good for you? Not in this case.
Ozone IV or Direct Injection is generally done with a 27g butterfly needle and 20 – 50 cc’s of ozone gas infused directly in a vein at a normal rate of 1 – 2 cc’s a minute. – link
My fiance laughs this off. The treatment is being given by a pre-med microbiology major who went to UCLA. She was told that IV Ozone is legal here and that doctors and naturopaths can administer it. What is a naturopath?
Naturopathy, or naturopathic medicine, is a form of alternative medicine based on a belief in vitalism, which posits that a special energy called vital energy or vital force guides bodily processes such as metabolism, reproduction, growth, and adaptation. Naturopathy favors a holistic approach with non-invasive treatment and generally avoids the use of surgery and drugs. Among naturopaths, complete rejection of biomedicine and modern science is common. – wiki
Interesting. So it is legal for a person who rejects modern science, a person without a medical license of any kind, to injecting a gas into someone’s vein while making a claim that this will have a positive medical benefit? Even if this is legal, it seems like a mind bogglingly bad move. People take anti-oxidants and even sleep on earthing sheets to prevent oxidative stress. Why would anyone introduce oxidation stress directly into the body?
Remember that song by the band Sweet titled “Love is like Oxygen“? The main hook says it well: “You get too much you get too high, not enough and you’re going to die.”
As I said, ozone injected into the bloodstream quickly forms hydrogen peroxide when it reacts with water in your blood. A serious complication can result: Intravenous hydrogen peroxide’s rampage can cause vasculitis.
Vasculitis occurs when your immune system mistakenly sees blood vessel cells as foreign. The immune system then attacks those cells as if they were an invader, such as a bacteria or virus. It’s not always clear why this happens, but an infection, some cancers, certain immune system disorders or an allergic reaction may serve as the trigger.
Blood vessels affected by vasculitis become inflamed, which can cause the layers of the blood vessel wall to thicken. This narrows the blood vessels, reducing the amount of blood — and therefore oxygen and vital nutrients — that reaches your body’s tissues. In some cases, a blood clot may form in an affected blood vessel, obstructing blood flow. Sometimes instead of becoming narrower, a blood vessel may weaken and form a bulge (aneurysm), a potentially life-threatening condition.
Here’s more on the damages of hydrogen peroxide. Some people have that injected or they drink it. Bad idea. Don’t be fooled by the term “Food grade” hydrogen peroxide. That doesn’t mean you can drink it! It means it is strong enough to use on cooking surfaces to kill germs. It will also cause serious damage if you try to drink it. Don’t.
Hydrogen peroxide can be harmful if swallowed, especially the concentrated solutions sold in some health food stores. “Food grade” peroxide is a very strong corrosive solution. It contains 35% hydrogen peroxide, a concentration that is more than ten times stronger than the 3% peroxide approved for use on the skin. Food grade hydrogen peroxide is approved by the FDA to clean food surfaces and for certain bleaching and disinfecting tasks in food production. The FDA requires that any peroxide that might remain in food be broken down into oxygen and water before the food reaches the consumer. Drinking food grade hydrogen peroxide can cause vomiting, severe burns of the throat and stomach, trouble breathing, bleeding in the stomach or intestine, symptoms of stroke, and even death. As it absorbs from the stomach or intestine, it can sometimes form bubbles in the blood vessels and block blood flow to parts of the body or brain. If it gets in the eyes, it can damage the corneas and even cause blindness. Direct skin contact with food grade hydrogen peroxide can cause blistering or burns, and breathing its vapors can cause serious breathing problems up to 72 hours later.
Hydrogen peroxide injections can have dangerous side effects. High blood levels of hydrogen peroxide can create oxygen bubbles that block blood flow and cause gangrene and death. Destruction of blood cells has also been reported after intravenous injection of hydrogen peroxide. A few people can also have serious allergic reactions to hydrogen peroxide. A 1993 review article also found some research evidence that too much oxygen in the body’s tissues may damage genetic material and promote abnormal growth. – link
Claims that diluted hydrogen peroxide may be taken intravenously or even orally for treating various sicknesses, including cancer, have been shown to be fraudulent, dangerous, and illegal, using “misbranding” and language explicitly prohibited by the Code of Federal Regulations, and have caused several deaths. – link
So, if you want to age quickly from the inside or possibly die from a blood clot in your lung or a burst blood vessel, try some IV ozone therapy! Hey, it might cure you of something. Might.
Here is a list of California Clinics that provide ozone therapy, although I don’t know any that would inject you with ozone gas directly.
Have you ever been to the ER or taken a ride in an ambulance? They gave you oxygen right? Might be a bad idea as pure O2 it is damaging to the brain:
… growing research suggests that inhaling straight oxygen can actually harm the brain. For the first time, a new UCLA brain-imaging study reveals why. Published in the May 22 edition of Public Library of Science (PLoS) Medicine, the findings fly in the face of national guidelines for medical practice and recommend a new approach that adds carbon dioxide to the mix to preserve brain function in patients.
“For decades, the medical community has championed 100 percent oxygen as the gold standard for resuscitation. But no one has reported what happens inside our brains when we inhale pure oxygen,” explained Ronald Harper, distinguished professor of neurobiology at the David Geffen School of Medicine at UCLA. “What we discovered adds to a compelling body of evidence for modifying a widely practiced standard of care in the United States.”
Harper’s team used functional magnetic resonance imaging (fMRI) to capture detailed pictures of what occurs inside the human brain during two different breathing scenarios. The technique detects subtle increases in blood flow triggered by the activation of different parts of the brain, causing these regions to glow or “light up” on the color scan.
The researchers scanned the brains of 14 healthy children, ages 8 15, as they inhaled 100 percent oxygen through a mouthpiece, and monitored their breathing and heart rates. After waiting eight minutes for the youngsters’ breathing to return to normal, the team added 5 percent carbon dioxide to the gas mixture and repeated the scan. A comparison of the two scans revealed dramatic differences.
“When the children inhaled pure oxygen, their breathing quickened, resulting in the rapid exhalation of carbon dioxide from their bodies,” said coauthor Paul Macey, associate researcher in neurobiology. “The drop in carbon dioxide narrowed their blood vessels, preventing oxygen from reaching tissue in the brain and heart.”
That’s when something surprising happened on the MRI scan. Three brain structures suddenly lit up: the hippocampus, which helps control blood pressure; the cingulate cortex, which regulates pain perception and blood pressure; and the insula, which monitors physical and emotional stress. All this activity awakened the hypothalamus, which regulates heart rate and hormonal outflow. Activation of the hypothalamus triggered a cascade of harmful reactions and released chemicals that can injure the brain and heart.
“Several brain areas responded to 100 percent oxygen by kicking the hypothalamus into overdrive,” explained Harper. “The hypothalamus overreacted by dumping a massive flood of hormones and neurotransmitters into the bloodstream. These chemicals interfere with the heart’s ability to pump blood and deliver oxygen the opposite effect you want when you’re trying to resuscitate someone.”
When the children inhaled the carbon dioxide-oxygen mix, the hypothalamus’ hyperactivity vanished from the MRI scan.
“Adding carbon dioxide to the oxygen relaxed the blood vessels, allowed oxygen to reach the heart and brain, calmed the hypothalamus and slowed the release of dangerous chemicals,” said Macey. “Pure oxygen kindles the match that fuels a forest fire of harm to the body,” said Harper. “But a little whiff of carbon dioxide makes it all go away.”
Based on their findings, the researchers strongly encourage healthcare providers to add carbon dioxide to oxygen dispensation, especially when resuscitating infants or administering oxygen for more than a few minutes. The new direction could hold particular implications for patients of stroke, heart attack, carbon monoxide poisoning and any long-term oxygen therapy.
“When in doubt about a case, the current medical approach is to increase oxygen levels and wait to see if the patient improves,” explained Harper. “But no one has ever scanned patients’ brains to examine how they respond to oxygen therapy.”
Earlier data on high oxygen’s harmful effects have already resulted in policy changes overseas. Instead of using straight oxygen, many European hospitals now resuscitate patients with room air, which contains a mixture of nitrogen, oxygen and carbon dioxide; or with a blend of oxygen and carbon dioxide.
Why would 100% oxygen be bad to breathe?
We breathe air that is 21 percent oxygen, and we require oxygen to live. So you might think that breathing 100 percent oxygen would be good for us — but actually it can be harmful. So, the short answer is, pure oxygen is generally bad, and sometimes toxic.
When pure O2 is introduced to the lungs, autonomic reflex increases respiration. The increased rate of breathing means that a much larger load of carbon dioxide is released from the body, which causes the blood vessels to constrict. Despite the increased amount of available oxygen in the lungs, the circulatory system is hampered, and cannot deliver precious O2 as well as it could when breathing normal atmosphere.
… The introduction of pure oxygen prompts the hypothalamus to flood the body with a cocktail of hormones and neurotransmitters which serve to hamper heart rate, and further reduce the circulatory system’s effectiveness. But Harper also found that by adding a mere 5% CO2, all the detrimental effects found in pure oxygen are negated.
Do cells die from lack of Oxygen? Perhaps not. It may be the quick re-introduction of oxygen that finishes them off from a dormant state.
… Upon examining heart cells and neurons deprived of oxygen under a microscope, Dr Lance Becker of the University of Pennsylvania found there was no indication that the cells were dying after five or six minutes. In fact, they seemed to endure the state for up to an hour without adverse affect. Given this unexpected observation, the researchers were forced to investigate why human resuscitation becomes impossible after only a few minutes of clinical death. The answer they uncovered was that the body’s cells were not dying of oxygen starvation; they were expiring due to reperfusion–the sudden reintroduction of oxygen to a dormant cell. Inside the cells, the culprit seems to be in the mitochondria, which is the cell’s power plant where sugar and oxygen are converted to usable energy. Mitochondria are also responsible for apoptosis–the organized, controlled self-destruction of a cell. Normally apoptosis occurs in situations such as the cell being damaged beyond repair, infected by a virus, an attempt to prevent cancer, or aiding in initial tissue development. The process effectively kills and dismantles the cell allowing the body’s usual waste management functions to carry the cell’s remains away. For reasons not entirely clear, reperfusion triggers apoptosis–the oxygen intended to save the cell actually causes cellular suicide.
Armed with this new information about how cells react to oxygen, it is clear that current emergency care is not altogether ideal, and new protocols are under investigation. Dr Becker proposes that induced hypothermia may slow cell degradation, and if a means can be found to safely reintroduce oxygen to tissues, a clinically dead person–who still has trillions of living cells–could be resuscitated after being an hour dead.
Is less oxygen better? Meditation reduces O2 consumption and increases life:
Although people who meditate knew that the body can become unusually quiet, it was striking scientific news that meditation is producing significantly deeper rest than sleep. This is determined by measuring how much oxygen is consumed. In sleep, oxygen consumption gradually decreases about eight percent over four or five hours. In meditation, it drops 10 to 20 percent in the first three minutes (Benson 1975:64).
The amount of oxygen an animal consumes changes moment from moment, being controlled by a complex process of the body called metabolism. We can indirectly affect metabolism by changing the level of physical activity—resting, running, eating, sleeping, or meditating—but we cannot control it directly. We don’t lower our oxygen consumption when holding the breath, because the tissues go right on consuming oxygen from the bloodstream according to their need and at approximately the same rate. So, this significant lowering of the consumption of oxygen in meditation implies a deep, complex, and organized shift in what the body is up to. It is especially significant considering that most meditators have no idea it is happening.
Benson’s original work on oxygen consumption has held up well. In 1996 Murphy and Donovan reported that over 40 studies have shown reduction of oxygen and carbon dioxide elimination. They report that oxygen consumption has been reduced by 55% and carbon dioxide elimination by 50%, and that breath rates have been seen as low as one breath per minute.
Too little oxygen is definitely a bad thing. It depends on your activity level too:
Most people are not aware of the body’s enormous increase in oxygen requirements caused by an increase in physical activity. Strenuous exercise like cross-country running results in a greatly increased need for oxygen, which is evidenced by deep and rapid breathing. Even mild exercise like getting up and walking around a room may double the air intake. – link
In the blood, oxygen is bound to haemoglobin, a protein in red blood cells. … In peripheral tissues, oxygen again diffuses down a pressure gradient into cells and their mitochondria, where it is used to produce energy in conjunction with the breakdown of glucose, fats and some amino acids.
Hypoxia (oxygen deprivation) can result from a failure at any stage in the delivery of oxygen to cells. This can include decreased partial pressures of oxygen, problems with diffusion of oxygen in the lungs, insufficient available haemoglobin, problems with blood flow to the end tissue, and problems with breathing rhythm. Experimentally, oxygen diffusion becomes rate limiting (and lethal) when arterial oxygen partial pressure falls to 40 mmHg (5.3 kPa) or below. … Almost all the oxygen in the blood is bound to hemoglobin, so interfering with this carrier molecule limits oxygen delivery to the periphery. Haemoglobin increases the oxygen-carrying capacity of blood by about 40-fold … When the ability of haemoglobin to carry oxygen is interfered with, a hypoxic state can result. – link
Pilots must be aware of the dangers of hypoxia, O2 starvation:
The effects of hypoxia on a given person cannot be accurately predicted. For example, a person may be relatively unaffected one day, but highly susceptible the next. It is difficult to detect hypoxia, because its victims are seldom able to judge how seriously they are affected, or if they are affected at all. The unpleasant sensations experienced in suffoca-tion are absent in the case of hypoxia. Blurring of vision, slight shortness of breath, a vague, weak feeling, and a little dizziness are the only warnings. Even these may be absent or. so slight as to go unnoticed.
… BELOW 10,000 FEET.- At or below 10,000 feet, some effects of hypoxia may be present. Generally, the eye is the first part of the body to suffer effects of hypoxia. Even at a relatively low altitude of approximately 5,000 feet, where no other effect of hypoxia can be detected, night vision is appreciable reduced. At 10,000 feet, night operations may be seriously handicapped by poor night vision, which is due to mild oxygen starvation. Thus, the use of supplemental oxygen on night flights above 5,000 feet is required. Although hypoxia affects the eyes in the daytime as well as at night, the results during the day are usually not as noticable below 10,000 feet.
BETWEEN 10,000 AND 15,000 FEET.- Although efficiency may be considerably impaired at 10,000 to 15,000 feet, death from oxygen starvation at these altitudes is virtually unknown. The greatest dangers are from errors in judgment or performance due to drowsiness or mental confusion. At these altitudes, long flights without oxygen produce persistent drowsiness and excessive fatigue for many hours afterward. Frequently, persistent headaches develop soon after completion of the flight. For these reasons, the use of oxygen on flights above 10,000 feet is required. Portable oxygen systems are available for aircraft that do not have oxygen equipment.
BETWEEN 15,000 AND 20,000 FEET.- Flights at 15,000 to 20,000 feet, even for short periods, must not be attempted without the use of oxygen. Collapse and unconsciousness are common. Failure to use oxygen could result in death, especially when the situation is complicated by loss of blood in combat or by shock due to pain or fear.
Recommendation: Let Mother Nature do her thing. Go for a jog to get more oxygen. Your body has evolved an innate intelligence over billions of years and it will take care of your oxygen needs well … as long as you don’t go somewhere with too little O2 or try to overdose yourself on the stuff.