Xenophilia (True Strange Stuff)

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Damn, I have adult onset type 1 prediabetes (An Updated Guide to Healthy Living)

Posted by Anonymous on June 27, 2014

I was recently diagnosed with prediabetes from an A1C protein test. This test measures 3 month average blood sugar. Having blood sugar problems does explain many things, but I’m nastily surprised. I’m a white male, thin, not overweight, I get moderate to heavy exercise (although I sit most of the day), and I don’t drink sodas or eat sweets (although I have been having two bananas each morning in my shake and plenty of carbs with meals).

Update: For the past few months I’ve greatly improved my diet, exercise, and sleep habits, and yet, my fasting blood sugar has improved little. On 8/6/2014 I got tested for several things to better understand my prediabetes diagnosis. Today on 8/10/2014 I was distressed to find that I am positive for antibodies to the tyrosine phosphatase–like molecule IA-2 (islet cell antigen 512), which is an indicator of Diabetes Type 1.  See latent autoimmune diabetes in adulthood (1)

“Although LADA may appear to initially respond to similar treatment (lifestyle and medications if needed) as type 2 diabetes, it will not halt or slow the progression of beta cell destruction, and people with LADA will eventually become insulin dependent.” – link

Oh Hell! This is not happening to me. My immune system is killing my pancreas? What the #$)&!? Could it be a false positive? Reversible?  I don’t have GAD autoantibodies at this time.

NEGATIVE: Insulin autoAB (IAA) , Pancreatic islet cell AB (I.C.Ab) (screening), Glutamate decarboxylase 65 AB (GAD65).

… most who test positive for both GAD and ICA progress rapidly toward insulin dependency.

POSITIVE: IA-2 Ab, aka ICA-512, aka islet cell Ag 512. So, the I.C.Ab that I’m negative for above, I’m actually positive for. They did a screening that was negative (below a certain threshold), but I was positive in the actual titer, the amount measured.

Not tested yet: insulinoma-associated autoantibody, zinc transporter ZnT8. 

What about the risks with just IA-2?

Individuals with no clinical symptoms, but who have autoantibodies to IA-2 and GAD, have an ∼50% risk of developing type 1 diabetes within 5 years and an even higher risk within 7–10 years. – link

As autoimmunity in type 1 diabetes progresses from initial activation to a chronic state, there is often an increase in the number of islet autoantigens targeted by T-cells and autoantibodies.[42,43] This condition is termed “epitope spreading.” There is convincing evidence that islet autoantibody responses against multiple islet autoantigens are associated with progression to overt disease.[42]  - link

How did I get this in the first place?

The best answer I’ve found so far is that I had a genetic defect (MHC haplotype / HLA genes) and when I encountered a real pathogen similar to IA-2, inherent abnormalities in my control mechanisms for the prevention of autoimmunity caused my body to generalize the attack (I have Sjogren’s SS-B antibody, and now IA-2).

An epitope is an antigenic determinant, or a site on the surface of an antigenic molecule, to which a single antibody binds. Epitope spreading (ES) refers to the development of an immune response to epitopes distinct from, and noncross-reactive with, the disease-causing epitope. … ES is a normal feature of a protective immune response … the immune system depends on diversification.  – link

People with certain HLA antigens are more likely to develop certain autoimmune diseases, such as type I diabetes, ankylosing spondylitis, celiac disease, SLE (systemic lupus erythematosus), myasthenia gravis, inclusion body myositis, Sjögren syndrome, and narcolepsy.[6]

- link

How long do I have? What does the research say is my best hope at this time?

… The best therapeutic option in LADA patients (while waiting for trials to prevent β-cell exhaustion) is to achieve good metabolic control and prevent chronic complications. … prevention of β-cells from complete destruction should be attempted. …

glitazones have the potential to preserve endogenous insulin secretory reserve, and from many of the models studied, improvement in glucose metabolism is accompanied by a reduction in circulating insulin concentration (59). There is interesting evidence that glitazones increase insulin synthesis and the insulin content of islet cells as well as improve the secretory response of islets (60). In addition to its hypoglycemic effect, troglitazone has been shown to possess in vitro anti-inflammatory properties, as shown by the reduction of cytokines such as tumor necrosis factor-α and γ-interferon (61). The latter mechanism could explain why, in the experimental model of the NOD mouse, troglitazone protects animals from diabetes development (62). Also, another compound of the same family of drugs—rosiglitazone—has been shown to possess similar effects in reducing diabetes incidence of autoimmune diabetes (63). – link

 

DiaPep277 holds promise not only for people with type 1 diabetes but also for those with LADA (latent autoimmune diabetes in adults).  … At diagnosis today, she says, only an estimated 10 to 15 percent of beta-cell function remains. “It’s not a lot, but if you have to lose 85 to 90 percent of your beta cells to develop the symptoms of diabetes, it might mean that if you can preserve 20 to 25 percent, it might be enough” to keep from becoming insulin-dependent. Dr. Raz sees DiaPep277 being used as a preventive method in the future, noting that results of the Diabetes Prevention Trial 1 in the United States showed that type 1 diabetes can sometimes be predicted several years in advance. “The best time to treat would be when you still have a large reserve of beta cells—several years before the clinical diagnosis of diabetes,” he explains. For now, however, Dr. Elias is quick to point out that DiaPep277 is not a cure for type 1 diabetes and will not prevent the disease. – link
 
DiaPep277® is a synthetic peptide of 24 amino acids derived from the sequence of the human heat shock protein 60 (Hsp60). The peptide modulates the immune response that leads to autoimmune diabetes by diminishing or blocking the immunological destruction of beta cells. – link
 
There is also the work at Viacyte to produce an implant that works as an artificial pancreas:

By acting essentially as a replacement endocrine pancreas, the source of insulin and other regulatory hormones produced in our bodies, ViaCyte’s VC-01 combination product has the potential to be a virtual cure for type 1 diabetes

What is IA-2 (also known as ICA512)?

IA-2 is a major autoantigen in type 1 diabetes. Autoantibodies to IA-2 appear years before the development of clinical disease and are being widely used as predictive markers to identify individuals at risk for developing type 1 diabetes. IA-2 is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase family and is an integral component of secretory granules in neuroendocrine cells. Its role in islet function is unclear. – link

Meanwhile, are my T-Cells constantly killing my pancreas cells? Does something bring on the attack? How much of my pancreas is still working? Does the physical pain in my pancreas mean something? Did my recent high C-Reactive Protein test (a general marker for inflammation) result from my eating gluten that day or not getting enough sleep? How many of the things below for Type 2 pre-diabetes help for LADA?

There is no established management strategy for people diagnosed with LADA.  – link

Do Beta Cells regenerate?

Yes. The “insulin-secreting beta cells of the pancreas, which are either killed or become dysfunctional in the two main forms of diabetes, have the capacity to regenerate. … vascular endothelial growth factor A (VEGF-A) is important for development of the islets’ blood supply and for beta-cell proliferation.” – link

“In 2009, researchers in Pittsburgh led by Dr. Andrew Stewart found that, in humans, the proteins cdk-6 and cyclin D1 caused beta cells to regenerate after they had been destroyed by diabetes. Cdk-6 is not easily measurable in rodents (where most of the research is done), so it had not been previously studied. ” – link

Keep the sugar/carbs down:

A study done in Seattle found that beta cells subjected to high glucose levels (about 288 mg/dl in a test tube) lost function rapidly. But when switched to a low-glucose environment (about 15 mg/dl), most of them recovered normal insulin production.

The following is a collection of what most people interested in optimum health should consider.

What is prediabetes?

Insulin hormone normally triggers your body to remove glucose from your blood by shuttling it into your cells to burn as energy. This action keeps your blood sugar reading within a healthy range. Prediabetes is a condition where your fasting blood glucose is over a concentration of 100 mg/dl because either your cells have developed a resistance to insulin (Type 2 diabetes, most commonly) or your pancreas is not producing the insulin required (Type 1 diabetes)… or both.  Type 1 diabetes is an autoimmune disorder where T cells mediate the destruction of the insulin-producing beta cells in your pancreas. Type 2 diabetes is a metabolic disorder of insulin resistance in many cells and it can progress to stress-induced (we think) death of the beta cells.

How can I tell if my pancreas is producing enough insulin?

The C-peptide level may be measured to see if any insulin is still being produced by the body. It may also be measured in cases of hypoglycemia (low blood sugar) to see if the person’s body is producing too much insulin.

Results: The standard range is 0.5 – 6.3 ng/mL. My fasting result was 1.5 ng/mL.

“Anything below the normal range of 0.5 to 3.0 ng/ml of blood means that insulin production has slowed down abnormally, and generally indicates type 1 diabetes. Type 2s, on the other hand, will often yield C-peptide results in the normal range, meaning their fluctuating blood sugars must be due to insulin resistance, rather than decreased production.”

Glad to be still making insulin, now to get my fasting blood sugar under control…

Why is it prediabetes dangerous?

Untreated, it will progress to full diabetes which kills one person every six seconds. Even if you never become diabetic, having a high fasting blood sugar is correlated with a shorter life, brain shrinkage, dementia and coronary artery disease.

What caused my prediabetes?

My car accident? One site says, “an automobile accident with injury can negatively affect glucose metabolism and result in blood levels far above 100 mg/dL, even during fasting.” How long does that last? I still have back pain from time to time from being rear ended in a car accident a few years ago.

I eat late, work out late (sporadically), don’t sleep enough, and by the morning when breakfast rolls around, I still have high blood sugar. My body is constantly producing insulin and it is now resistant, probably, unless I have rare adult-onset Type 1 diabetes where my beta-cells are not producing enough insulin.

Either way, resistance or lack of insulin production means I can’t get the glucose out of my blood, so I’m not storing enough for use when needed.  Insulin resistance also leads to dangerous fluctuations in blood sugar and that can cause panic feelings, mental fog, forgetfulness, and other serious issues such as damage to the heart and other organs.

Diabetes kills one person every six seconds and afflicts 382 million people worldwide, according to the International Diabetes Federation, which has been canvassing the help of people ranging from celebrity chef Jamie Oliver to Bob Marley’s nephew to raise awareness about the problem.

The number of diabetes cases has climbed 4.4 percent over the past two years and is more than 5 percent of the world’s population, according to new figures the Brussels-based federation released today. The number of people affected by the disease is expected to climb 55 percent to 592 million by 2035 as factors including poor diet, a more sedentary lifestyle, increases in obesity and life expectancy fuel an epidemic, it said. There were only 285 million sufferers worldwide in 2009.

http://www.bloomberg.com/news/2013-11-14/diabetes-kills-one-person-every-six-seconds-new-estimates-show.html

Pre-diabetes and diabetes are linked to a rapid loss of brain function, far more than would be expected from normal ageing, found the two-year Sydney Memory and Ageing Study

http://www.diabeteseducatorsupdate.com.au/latest-news/even-pre-diabetes-courts-dementia

What is Insulin Resistance (IR)?

The liver and muscles are your two most important organs that respond to insulin. A healthy liver responds to insulin by not producing glucose. A healthy muscle responds by using glucose. An insulin resistant liver, however, produces unwanted glucose (and more fat), and insulin resistant muscle cells cannot absorb glucose from the bloodstream, leading to high levels in the blood. Blood vessels become resistant, too. Insulin-resistant blood vessels don’t open up as well and don’t prevent the buildup of fatty plaques that can cause arteries to harden. It makes sense, therefore, that IR is correlated with stroke, even in non-diabetics.

What to Do?

Get a Blood Sugar Monitor and Start a Log

I’ve started a log of what I eat, how much I sleep, exercise and my blood sugar every morning. With this data, I’ve been plotting correlations to see what effects my blood sugar the most. Fasting blood glucose level seems to be an overall health indicator. Stable lower blood sugar levels correlate with long life and a healthy brain. Things that lower your insulin resistance (and put you in a healthy fasting glucose range) are generally good for your overall health.

Your Meter May Be Wrong

Some meters and/or test strip batches, even when not expired, seem to produce terribly inaccurate results! In one morning with my Bayer Contour 7151H meter with Bayer strips from Amazon that expire 2015-09 (lot DW3JJ3F03D), I had readings between 82 and 131. Am I under 100? No idea. Others have had problems with the Contour’s accuracy. I called Bayer, highly annoyed, and they are sending me the new latest model which they say is 10% to 15% more accurate. After months of testing, and using my morning result to change my behavior the next day, I discovered that my data may be useless? That is, apparently, a lot of sticking myself for nothing. And, yes, I washed my finger each time and quickly used the first blood that came out (evaporation concentrates blood sugar quickly in that little drop.) Even the test solution shaken each time and dropped with a fresh drop onto wax paper had a 10 point spread with the same batch of strips. As you can see, it appears that my blood sugar fell from 122 mg/dL to 82 mg/dL in three minutes, then then went up to 131 mg/dL four minutes later.

Unanswered Question: Can blood sugar change that fast, every few minutes, as fast as blood pressure?

The first drop of blood you squeeze out of your finger may contain more interstitial fluid the solution surrounding your cells, which can give a lower reading… but as you can see, my first test was higher than the next 5. Throwing out the highest (131 & 122) and lowest (82 & 85) readings my average this morning is 106.

20140719-091746-33466221.jpg

Meters like this measure glucose in “whole blood” which consists of plasma (liquid), and cells, mainly red cells. The hematocrit is the percentage of red cells in your blood, normally about 45% for men and 40% for women according to this.  The meter has no way of knowing your current hematocrit, so it uses a set reference to yield “plasma-equivalent” results. This is why the reading is only an estimate.

According to Kaiser, the standard range is 39.0 – 51.0 % and my latest reading was 43.2. From one study, it seems that athletes have lower hemocrits:

“… physiological values of hematocrit in these athletes are comprised between 36 and 48%; (b) “low” hematocrit (<40%) was associated with a higher aerobic capacity; (c) subjects with the higher hematocrits (>44.6%) were frequently overtrained and/or iron-deficient… ” – link

Some foods like red meat and dark green leafy veggies, beans, raisins, prunes, broccoli, citrus fruit and tomatoes can increase your heamatocrit, according to this page. If my hematocrit goes up from 43 to say, 45, and my meter has a set standard, this would, I assume, change make my “plasma-equivalent” glucose reading. With more red blood cells per volume, I would have (false) higher glucose readings.

How much does hematocrit vary from minute to minute, hour to hour?

C-peptide test

Verify the reason for the high fasting glucose with a C-peptide test. My 5.5 A1C reading says my average blood glucose over the past 3 months has been 110mg/dL which is high. My 1.4 ng/mL C-peptide test says I’m still making insulin, so I probably have an insulin-resistance problem (type 2)  rather than an autoimmune problem (type 1).

Fix Your Liver

The pancreas regulates blood sugar when you eat, but a larger organ, your liver, regulates your blood sugar while you are not eating.

The liver, your largest internal organ at 3-4 lbs, works 24 hrs/day to keep you alive by performing hundreds of critical functions, including the ability of the body to store and synthesize glucose.

Claims about things that help the liver:

Drink green tea which helps prevent fat build up in your liver, get enough B vitamins, eat bitter raw greens like kale and dandilion greens, take fish oil, raw milk from pastured grass-fed cows, eat two heaping tablespoons of ground organic flax meal which binds to hormone receptor sites, preventing excess hormones including synthetic xenoestrogens from plastics and other chemicals, from floating around your bloodstream.

Avoid these to protect your liver :

Pesticides prevalent in non-organic foods, especially non-organic meat, dairy products, butter, and eggs which have more pesticides than even non-organic greens and vegetables, avoid food additives, bottled water from plastic bottles, all sodas and soft drinks except sparkling water in glass bottles.

Exercise

An hour of afternoon exercise may lower glucose levels until the next morning, affecting the fasting blood sugar test.

Some people respond very well to short high intensity training three times per week, combined with simply moving as much as possible (not sitting) during the day. In four weeks, one BBC  reporter had a 20% improvement in insulin resistance in a lab glucose tolerance test. I’ve started push-ups, sprints (high intensity training), and walking 10,000 steps per day as monitored by my FitBit.

Note: Don’t overdo it. In my fanatical attempt to get my blood sugar down, three days in a row of high intensity training caused heart attack symptoms and almost sent me to the ER. It takes a full 24 to 48 hours for muscle (including your heart) to recover fully after being torn down. Do only three days a week of high intensity training, skipping a full day between sessions to recover.

Intermittent Fasting

The ideas is that if I clear my glucose by breakfast each day, then my pancreas will have a chance to rest (no need to produce insulin) and I should be able to regulate my blood sugar better.

So I thought. As I am underweight, this may have been a very bad idea. Waiting until my blood sugar level came down one morning until I ate, the result was that I got very shaky, then started to black out with a blood sugar level of 103 after 14 hours of fasting. I had dull chest pains and an panic adrenaline reaction, tingling in my hands and feet, my left foot cramped up for about 20 minutes and the bottom of my right foot felt like I was standing on a heater. That symptom, the hot foot, remained on and off for days.

Don’t Bloat Yourself with Food

Eat a little less (until no longer hungry, instead of until full), again to get back to an ability to store and clear the glucose with insulin.

Get Enough Deep Sleep

I’ve shifted my work hours so I eat an hour earlier, work out earlier, and get more sleep. It sounds mundane, but getting enough sleep seems to be the key for me.  University of Chicago Med Center researchers found that “suppressing deep sleep for just three nights causes a 25 percent drop in insulin sensitivity. the researchers say that the decrease in insulin sensitivity after three nights of bad sleep is equivalent to gaining 20 to 30 pounds.”

I normally pop awake after 6.5 to 7 hours of sleep, but going to sleep extra early and having a swig of raw goat’s milk before bed gave me an 8.5 hour sleep with a decent blood sugar reading the next morning. The effect of proper recovery seems cumulative. 7 hours sleep the following night was enough for my first fasting blood sugar under 100 in a week.

One study found that just a single night of inadequate sleep increases insulin resistance.

Get up! Get on up! Walk or Stand Rather than Sit Most of the Day

Standing at your desk rather than sitting, you burn about 50 calories per hour more and your  heart beats about 10 beats per minute more.

“… prolonged sitting has not only been linked to problems with blood glucose control, but also a sharp reduction in the activity of an enzyme called lipoprotein lipase, which breaks down blood fats and makes them available as a fuel to the muscles. This reduction in enzyme activity leads to raised levels of triglycerides and fats in the blood, increasing the risk of heart disease.” – link

Cinnamon

Add cinnamon to meals which helps insulin work.

“Yes, it does work,” says , a research nutritionist with the University of California, Davis. He authored a recent published in the Journal of Medicinal Food that concluded that cinnamon lowers fasting blood glucose. “According to our results, it’s a modest effect of about 3 to 5 percent,” Davis says. This is about the level of reduction found in the older generation of diabetes drugs, he says. That makes the findings of interest not just to the 25 million Americans who already have diabetes, but also to the 80 million other people — of us — who have elevated fasting blood-glucose levels.
NPR

The most common kind, cassia cinnamon can contain high levels of coumarin, so keep it under 1 teaspoon per day to avoid reversible liver toxicity in case you are one of the few people who is sensitive to it.

- Eat a few fresh basil leaves with meals.

- Cut down from 2 grams/day to 1 gram of Vitamin C which competes with glucose for insulin transport into your cells. One person reported false positive high A1C and FBG readings from 4 grams of vitamin C.

- Started taking chromium picolinate (200 mcg/day) which can lower fasting blood sugar and insulin levels. It seems to help insulin work better in people with type 2 diabetes.

 Avoid too much Selenium

Selenium is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes. Selenium is required for proper functioning of the thyroid gland, and may protect against cancer, so you need some. A recommended amount according to the NIH is 55 mcg/day.  A long term deficiency can lead to a syndrome where the immune system attacks the thyroid.  However, too much can kill you.

“Researchers have identified a hormone, selenoprotein P (SeP), produced and secreted by the liver as a previously unknown cause of insulin resistance.  … When the researchers gave normal mice SeP, they became insulin resistant and their blood sugar levels rose. A treatment that blocked the activity of SeP in the livers of diabetic and obese mice improved their sensitivity to insulin and lowered blood sugar levels. ” – link

The evolved reduced utilization of selenium-containing proteins in mammals raises important questions in human and animal nutrition. Selenoprotein expression is regulated such that people don’t need to rely so heavily on dietary selenium which is often present in excess amounts in the diet. – link

Brazil nuts, for example, contain very high amounts of selenium (68–91 mcg per nut) and can cause you to go over the safe upper limit if you eat too many. … Too much over time can also cause garlic breath and nervous system problems, among others. At extremely high intakes, selenium can cause severe problems, including difficulty breathing, tremors, kidney failure, heart attacks, and heart failure. – link

Selenium is found naturally in seafood, meat, poultry, eggs and dairy products as well as breads, cereals and other grains. (more) Is excess selenium causing insulin resistance and diabetes?  400 mcg is probably the safe upper daily limit for Selenium intake for adults. If you’ve watched the movie Evolution, you probably know that selenium is a key ingredient in dandruff shampoo.

You should also be aware that selenium compounds, including those used in some medicated dandruff shampoos, are not easily absorbed through the skin. Most of the selenium that enters the body quickly leaves the body, usually within 24 hours. Beyond what the body needs, selenium leaves mainly in the urine, but also in feces and breath. Selenium in the urine increases as the amount of the exposure goes up. Selenium can build up in the human body, however, if exposure levels are very high or if exposure occurs over a long time.  – link

Unanswered Questions:
Low carb? Evenly spaced carbs? Low fat or high (good) fat? Is intermittent fasting good for thin prediabetics with no weight issues?  Intermittent fasting (IF) when you are prediabetic causes swings in glucose, resulting in mental discomfort and potentially increased cortisol and cardiac death.

‘There seems to be rather a lot of slim, fit people, who have had an excellent diet for years, that seem to be either diabetic or pre-diabetic, What is going on?’  http://www.diabetes.co.uk/forum/threads/thin-fit-prediabetic-is-there-hope.43169/

What else can be done? Even for Type 1, there is new hope:

Sanford-Burnham Medical Research Institute (Sanford-Burnham) and UC San Diego School of Medicine scientists have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells (hESC), and implanting them under the skin in animal models of diabetes, sufficient insulin is produced to maintain glucose levels without unwanted potential trade-offs of the technology. The research suggests that encapsulated hESC-derived insulin-producing cells hold great promise as an effective and safe cell-replacement therapy for insulin-dependent diabetes.

“Our study critically evaluates some of the potential pitfalls of using stem cells to treat insulin-dependent diabetes,” said Pamela Itkin-Ansari, Ph.D., adjunct assistant professor in the Development, Aging, and Regenerative Program at Sanford-Burnham, with a joint appointment at UC San Diego.

“We have shown that encapsulated hESC-derived pancreatic cells are able to produce insulin in response to elevated glucose without an increase in the mass or their escape from the capsule. These results are important because it means that the encapsulated cells are both fully functional and retrievable,” said Itkin-Ansari.

In the study, published online in Stem Cell Research, Itkin-Ansari and her team used bioluminescent imaging to see if encapsulated cells stay in the capsule after implantation.

Previous attempts to replace insulin-producing cells, called beta cells, have met with significant challenges. For example, researchers have tried treating diabetics with mature beta cells, but because mature cells are fragile and scarce, the method is fraught with problems. Moreover, since the cells come from organ donors, they may be recognized as foreign by the recipient’s immune system — requiring patients to take immunosuppressive drugs to prevent their immune system from attacking the donor’s cells, ultimately leaving patients vulnerable to infections, tumors, and other adverse events.

Encapsulation technology was developed to protect donor cells from exposure to the immune system — and has proven extremely successful in preclinical studies.

Itkin-Ansari and her research team previously made an important contribution to the encapsulation approach by showing that pancreatic islet progenitor cells are an optimal cell type for encapsulation. They found that progenitor cells were more robust than mature beta cells to encapsulate, and while encapsulated, they matured into insulin-producing cells, which secreted insulin only when needed.

“We were thrilled to see that the cells remained fully encapsulated for up to 150 days, the longest period tested, said Itkin-Ansari. “Equally important is that we show that the progenitor cells develop glucose responsiveness without a significant change in mass — meaning they don’t outgrow their capsule.

“Next steps for the development of the approach will be to figure out the size of the capsule required to house the number of progenitor beta cells needed to respond to glucose in humans. And of course we want to learn how long a capsule will function once implanted. Given these goals and continued successful results, I expect to see the technology become a treatment option for patients with insulin-dependent diabetes,” said Itkin-Ansari.

http://health.ucsd.edu/news/releases/Pages/2014-03-25-stem-cell-derived-beta-cells-replace-insulin.aspx

Terms

Neurotoxin causes of autoimmunity – The immune system interacts extensively with the nervous system.  Some research suggests that the events that control the development of type 1 diabetes involve neurological factors, not only the immune system (Tsui et al. 2007). Over 200 chemicals are known to be neurotoxic in humans, and over 1000 are known to be neurotoxic in experiments. Whether these could be involved in type 1 diabetes development is not known. – link

Pancreatic b-cells –  Cells that make up 65-80% of the cells in the islets of Langerhans in the pancreas. The primary function of a beta cell is to store and release insulin. Diabetes mellitus can be experimentally induced for research purposes by streptozotocin or alloxan, which are specifically toxic to beta cells.

Streptozotocin (Streptozocin, STZ, Zanosar®) – a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. A glucosamine-nitrosourea compound. As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other mechanisms may also contribute. DNA damage induces activation of poly ADP-ribosylation, which is likely more important for diabetes induction than DNA damage itself.[3] Streptozotocin is similar enough to glucose to be transported into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. This explains its relative toxicity to beta cells, since these cells have relatively high levels of GLUT2.[4][5]

Alloxan – a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is beta cells) when administered to rodents and many other animal species. This causes an insulin-dependent diabetes mellitus (called “alloxan diabetes”) in these animals, with characteristics similar to type 1 diabetes in humans. Alloxan is selectively toxic to insulin-producing pancreatic beta cells because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter.

White flour contains diabetes-causing contaminant alloxan: … Studies show that alloxan, the chemical that makes white flour look “clean” and “beautiful,” destroys the beta cells of the pancreas. That’s right; you may be devastating your pancreas and putting yourself at risk for diabetes, all for the sake of eating “beautiful” flour. Is it worth it? – http://www.naturalnews.com/008191.html

Alloxan, in the presence of intracellular thiols, generates reactive oxygen species (ROS) in a cyclic reaction with its reduction product, dialuric acid. The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. [Some studies] found a significant difference in alloxan plasma levels in children with and without diabetes Type 1.[3]

File under: Damnit, why didn’t someone tell me this years ago when I still had a healthy pancreas!

Prodromal Period ( Prodromic Period ) – the time during which a disease process has begun but is not yet clinically manifest.  

Posted in Biology, Education, Food, Health, Mind, Survival | 3 Comments »

CA Bill 1381 – Second Chance at GMO labeling

Posted by Anonymous on May 28, 2014

20140527-181305.jpg

If you live in California, please contact your California state Senator ( http://findyourrep.legislature.ca.gov ) and ask him or her to vote YES on California State Bill 1381 in favor of labeling GMO foods. The vote will likely be tomorrow, Wednesday, May 28.

Posted in Food, Health, Politics | 1 Comment »

A Toxin By Any Other Name: Aspartame’s Name Changed to AminoSweet

Posted by Anonymous on April 11, 2014

Used as a sugar substitute and often marketed as Nutrasweet and Equal, aspartame is an excitotoxin that destroys the brain and body. Its use has been a controversial subject since the 1980s when the CEO of Searle, Donald Rumsfeld, pushed for it’s approval to be sold on the market. Now, its name is being changed, with FDA approval, to try to dupe millions into purchasing and consuming this toxin once again.

Aspartame, even renamed Amino Sweet, is not safe. This substance is made using genetically modified bacteria in the US, but according to a Monsanto source, the UK market does not have to eat genetically modified bacteria excrement. Many ‘low-calorie’ foods contain GMO aspartame, however, even overseas. Aspartame may cause blindness, cancer, and brain tumors.

Just as a reminder of who is pushing this excrement – quite literally – on the consumers of the United states, it was Mr. Rumsfeld who went on to become George W. Bush’s secretary of Defense, and crony-Capitalist agenda-pusher. This one substance has continually been shown to cause harm to human health, so why is the FDA renaming it instead of banning it completely from the food supply? There is considerable evidence that artificial sweeteners cause cancer, including aspartame specifically – so why not name it something more appropriate at least? ‘Sickeningly Sweet’ might be more appropriate.

Even saccharin eventually had to be made with a label, mandated by Congress, that says, “Use of this product may be hazardous to your health. This product contains saccharin, which has been determined to cause cancer in laboratory animals”. The FDA’s own toxicologist, Dr. Adrian Gross told Congress that without a shadow of a doubt, aspartame can cause brain tumors and brain cancer and that it violated the Delaney Amendment.

via » Aspartame’s Name Changed to Amino Sweet: A Toxin By Another Name is Still a Toxin Alex Jones’ Infowars: There’s a war on for your mind!.

Slowly poisoning someone is totally legal in the USA … as long as you make money from doing it. ;-)

Posted in Biology, Food, Health | Leave a Comment »

NASA Study: Civilization collapse difficult to avoid on current course

Posted by Anonymous on March 18, 2014

20140319-213029.jpgA new study sponsored by Nasa’s Goddard Space Flight Center has highlighted the prospect that global industrial civilisation could collapse in coming decades due to unsustainable resource exploitation and increasingly unequal wealth distribution.

Noting that warnings of ‘collapse’ are often seen to be fringe or controversial, the study attempts to make sense of compelling historical data showing that “the process of rise-and-collapse is actually a recurrent cycle found throughout history.” Cases of severe civilisational disruption due to “precipitous collapse – often lasting centuries – have been quite common.”

The research project is based on a new cross-disciplinary ‘Human And Nature DYnamical’ (HANDY) model, led by applied mathematician Safa Motesharrei of the US National Science Foundation-supported National Socio-Environmental Synthesis Center, in association with a team of natural and social scientists. The study based on the HANDY model has been accepted for publication in the peer-reviewed Elsevier journal, Ecological Economics.

It finds that according to the historical record even advanced, complex civilisations are susceptible to collapse, raising questions about the sustainability of modern civilisation:

“The fall of the Roman Empire, and the equally (if not more) advanced Han, Mauryan, and Gupta Empires, as well as so many advanced Mesopotamian Empires, are all testimony to the fact that advanced, sophisticated, complex, and creative civilizations can be both fragile and impermanent.”

By investigating the human-nature dynamics of these past cases of collapse, the project identifies the most salient interrelated factors which explain civilisational decline, and which may help determine the risk of collapse today: namely, Population, Climate, Water, Agriculture, and Energy.

These factors can lead to collapse when they converge to generate two crucial social features: “the stretching of resources due to the strain placed on the ecological carrying capacity”; and “the economic stratification of society into Elites [rich] and Masses (or “Commoners”) [poor]” These social phenomena have played “a central role in the character or in the process of the collapse,” in all such cases over “the last five thousand years.”

Currently, high levels of economic stratification are linked directly to overconsumption of resources, with “Elites” based largely in industrialised countries responsible for both:

“… accumulated surplus is not evenly distributed throughout society, but rather has been controlled by an elite. The mass of the population, while producing the wealth, is only allocated a small portion of it by elites, usually at or just above subsistence levels.”

The study challenges those who argue that technology will resolve these challenges by increasing efficiency:

“Technological change can raise the efficiency of resource use, but it also tends to raise both per capita resource consumption and the scale of resource extraction, so that, absent policy effects, the increases in consumption often compensate for the increased efficiency of resource use.”

Productivity increases in agriculture and industry over the last two centuries has come from “increased (rather than decreased) resource throughput,” despite dramatic efficiency gains over the same period.

Modelling a range of different scenarios, Motesharri and his colleagues conclude that under conditions “closely reflecting the reality of the world today… we find that collapse is difficult to avoid.” In the first of these scenarios, civilisation:

“…. appears to be on a sustainable path for quite a long time, but even using an optimal depletion rate and starting with a very small number of Elites, the Elites eventually consume too much, resulting in a famine among Commoners that eventually causes the collapse of society. It is important to note that this Type-L collapse is due to an inequality-induced famine that causes a loss of workers, rather than a collapse of Nature.”

Another scenario focuses on the role of continued resource exploitation, finding that “with a larger depletion rate, the decline of the Commoners occurs faster, while the Elites are still thriving, but eventually the Commoners collapse completely, followed by the Elites.”

In both scenarios, Elite wealth monopolies mean that they are buffered from the most “detrimental effects of the environmental collapse until much later than the Commoners”, allowing them to “continue ‘business as usual’ despite the impending catastrophe.” The same mechanism, they argue, could explain how “historical collapses were allowed to occur by elites who appear to be oblivious to the catastrophic trajectory (most clearly apparent in the Roman and Mayan cases).”

Applying this lesson to our contemporary predicament, the study warns that:

“While some members of society might raise the alarm that the system is moving towards an impending collapse and therefore advocate structural changes to society in order to avoid it, Elites and their supporters, who opposed making these changes, could point to the long sustainable trajectory ‘so far’ in support of doing nothing.”

However, the scientists point out that the worst-case scenarios are by no means inevitable, and suggest that appropriate policy and structural changes could avoid collapse, if not pave the way toward a more stable civilisation.

The two key solutions are to reduce economic inequality so as to ensure fairer distribution of resources, and to dramatically reduce resource consumption by relying on less intensive renewable resources and reducing population growth:

“Collapse can be avoided and population can reach equilibrium if the per capita rate of depletion of nature is reduced to a sustainable level, and if resources are distributed in a reasonably equitable fashion.”

The NASA-funded HANDY model offers a highly credible wake-up call to governments, corporations and business – and consumers – to recognise that ‘business as usual’ cannot be sustained, and that policy and structural changes are required immediately.

… a number of other more empirically-focused studies – by KPMG and the UK Government Office of Science for instance – have warned that the convergence of food, water and energy crises could create a ‘perfect storm’ within about fifteen years. But these ‘business as usual’ forecasts could be very conservative.

Continuity of Government, if the elites want it, is not going to be had by digging underground cities, stockpiling food, gas and water and waiting out the storm. The current fragile pyramid will not be maintained by the persecution of whistleblowers. Instead, the way to fix things is to get everyone to understand that we all fail if we don’t pull together. Teamwork or die.

Posted in Earth, Food, Politics, Space, Survival, Technology | 2 Comments »

Company proposes meat from celebrity tissue samples

Posted by Anonymous on March 17, 2014

20140316-203013.jpg“It’s people! Soylent green is made out of people”, to quote from the classic 1973 science fiction film and Charlton Heston’s memorable line. …

Once more life imitates art, and a startup called BiteLabs is looking for support to create meat products from celebrity body parts, aiming to take cells from willing celebs and using them to grow protein into test-tube meat.

LATimes.com spoke with a representative of the organization: “At the moment, our primary goal is to provoke discussion and debate around topics of bioethics and celebrity culture.” …

Los Angeles Times’ “Daily Dish” reports on the newest and ’coolest’ way to devour ourselves:

[...]Here’s how it will work, according to the BiteLabs website. A sample of tissue containing myosatellite cells (the type of cells that help repair and regrow damaged muscle) will be taken from a person during a biopsy. Those cells are multiplied in a lab using a medium that acts as an artificial blood to grow muscle.

Once the cells are mature enough, they will be ground and mixed with different kinds of meat, spices, fats and oils for flavor using one of the company’s “time-honored recipes for the creation of fine cured meats.” It will then be stuffed into casings, seasoned again then dry aged and cured before packaging for distribution.

The company outlines how this type of test-tube meat would eliminate environmental and ethical concerns associated with livestock production, claiming its celebrity meat production would require less than 1% of the land used in traditional farming. The site also notes, the lab meats will not be affected by growth hormones or come into contact with any pesticides or chemicals.

And as far as the celebrity angle, BiteLabs is hoping they can use celebrities to warm people up to the idea of consuming the meat. …

http://touch.latimes.com/#section/-1/article/p2p-79519061/

Posted in Food, Strange | Leave a Comment »

GMO Science Credibility Falls with Two Retracted Studies

Posted by Anonymous on March 11, 2014

The pesticide producers are one of the most powerful industries on the planet, the influence they possess is enormous. You have probably heard that an Elsevier journal has retracted the Seralini study which showed evidence of harm to rats fed a GMO diet, despite admitting they found no fraud or errors in the study.

This journal had also just recently appointed an ex-Monsanto employee as an editor – one could only guess the value of this strategy for the pesticide industry. Expect Seralini to sue as this story develops, as it appears he has a very strong case.

Alas, the scientific ground on which the genetic engineering of plants is built may now be shakier than ever, thanks to GMO promoting scientists like Dr. Pamela Ronald. A recent article in Independent Science News1 questions whether she’ll be able to salvage her career, as two of her scientific papers (published in 2009 and 2011 respectively) were recently retracted.

With the loss of her credibility, and the domino effect these retractions are likely to cause within the scientific field, the entire chemical technology industry stands to suffer a great blow to its scientific integrity.

“Her media persona… is to take no prisoners,” Jonathan Latham, PhD writes.2 “After New York Times chief food writer Mark Bittman advocated GMO labeling, she called him ‘a scourge on science’ who ‘couches his nutty views in reasonable-sounding verbiage.’ His opinions were “almost fact- and science-free” continued Ronald.

In 2011 she claimed in an interview with the US Ambassador to New Zealand: ‘After 14 years of cultivation and a cumulative total of two billion acres planted, GE crops have not caused a single instance of harm to human health or the environment.'”

She may have to turn down her criticism a notch, considering the fact that not one but two of her own studies were found to contain sizeable scientific errors, rendering her findings null and void. Questions have also been raised about a third study published in 2011, according to the featured article.

Public Face of GMOs Loses Scientific Credibility

Ronald’s research group claimed to have identified a molecule used by rice plants to detect pathogenic rice blight, as well as a quorum sensing molecule (meaning a molecule that can coordinate gene expression according to the density of the local population).

These two studies, both of which are now retracted,3, 4 formed the basis of her research program at the University of California in Davis, which is investigating how rice plants detect certain pathogenic bacteria.

Ronald blamed the erroneous work by long gone lab members from Korea and Thailand, referring to the errors as a “mix-up.” She didn’t name her bungling colleagues, however. And while media coverage applauded Ronald for “doing the right thing” by retracting the studies, the featured article5 questions whether she really deserves such accolades:

“[S]cientific doubts had been raised about Ronald-authored publications at least as far back as August 2012… German researchers had been unable to repeat Ronald’s discoveries… and they suggested as a likely reason that her samples were contaminated.

Furthermore, the German paper also asserted that, for a theoretical reason, her group’s claims were inherently unlikely. In conclusion, the German group wrote: ‘While inadvertent contamination is a possible explanation, we cannot finally explain the obvious discrepancies to the results…’

Pamela Ronald, however, did not concede any of the points raised by the German researchers and did not retract the Danna et al 2011 paper. Instead, she published a rebuttal.

The subsequent retractions, beginning in January 2013, however, confirm that in fact very sizable scientific errors were being made in the Ronald laboratory. But more importantly for the ‘Kudos to Pam’ story, it was not Pamela Ronald who initiated public discussion of the credibility of her research.

… Ronald’s footnotes [in the explanation that accompanied the retraction of her second article6 admit two mislabelings, along with failures to establish and use replicable experimental conditions, and also minimally two failed complementation tests. Each mistake appears to have been compounded by a systemic failure to use basic experimental controls.

Thus, leading up to the retractions were an assortment of practical errors, specific departures from standard scientific best practice, and lapses of judgment in failing to adequately question her labs’ unusual (and therefore newsworthy) results.”

The Snowball Effect of Retracted Studies

According to data from Thomson Reuters,7 the numbers of scientific retractions have climbed more than 15-fold since 2001. What many don’t realize is that even a small number of retracted studies can wreak absolute havoc with the science-based paradigm. Other scientists who have based their research on the results from studies that, for whatever reason, end up being retracted, are now perpetuating flawed science as well. In one example, two retracted medical studies led to the retraction of another 17.

In this case, the first of Dr. Ronald’s retracted studies has been cited eight times.8 The second? 113 times.9 That sounds like an awfully large cleanup job in a field that’s already heavily criticized for its preponderance of “lousy science,” to use the words of award-winning geneticist Dr. David Suzuki.

The Problem with GMO Plant Science

It’s important to realize that genetically engineered plants and animals are created using horizontal gene transfer (also called horizontal inheritance). This is in stark contrast to vertical gene transfer, which is the mechanism in natural reproduction. Vertical gene transfer, or vertical inheritance, is the transmission of genes from the parent generation to offspring via sexual or asexual reproduction, i.e., breeding a male and female from one species.

Horizontal gene transfer, on the other hand, involves injecting a gene from one species into a completely different species, which yields unexpected and often unpredictable results. Proponents of genetically engineered crops assume they can apply the principles of vertical inheritance to horizontal inheritance, but according to Dr. David Suzuki, this assumption is flawed in just about every possible way and is “just lousy science.”

Genes don’t function in a vacuum — they act in the context of the entire genome. Whole sets of genes are turned on and off in order to arrive at a particular organism, and the entire orchestration is an activated genome. It’s a dangerous mistake to assume a gene’s traits are expressed properly, regardless of where they’re inserted. The safety of genetically modified food is based only on a hypothesis, and this hypothesis is already being proven wrong.

The kind of horizontal gene transfer that is currently used to create new crop seeds tends to produce highly inflammatory foreign proteins. As one would expect, were there a connection, inflammation-based chronic diseases have indeed increased right alongside with the proliferation of GMO foods in the US. Clearly, Dr. Ronald never bothered to look at such data, and her declaration that “GE crops have not caused a single instance of harm to human health or the environment”10 is as lacking in scientific support as her retracted research.

Posted in Biology, Food, Health, Technology | Leave a Comment »

Kangaroo eats penguin

Posted by Anonymous on March 5, 2014

20140304-232010.jpgWHILE KANGAROOS ARE known to munch grass, with the addition of fruit, flowers, sap and bark for tree kangaroos, who knew they favour an occasional bite of meat?

Sam Murray, who captured this curious footage, happened upon this western grey kangaroo (Macropus fuliginosus) tucking into a penguin on the beach at Cape Le Grande national park, located east of Esperance, WA in March 2013.

“We were walking down to the beach in the late evening before sunset, and we noticed a group of five or six kangaroos gathered on the beach. We started towards them and all the others were quick to hop away, but not this smaller one,” Sam says.

“He was really quite focussed on what he was doing. Even when we got to within a metre and a half of him, he wouldn’t stop eating.”

Kangaroos sometimes eat meat

Professor Graeme Coulson, a zoologist at the University of Melbourne, explains that “All living macropods appear to be gentle herbivores. They [generally] lack the equipment to capture and kill other animals, or the digestive system to handle a meaty diet.”

While penguins aren’t a typical kangaroo snack, Graeme says that “Australia once had carnivorous macropods. The largest of these was Propleopus oscillans, which stood up to 2 m tall and had teeth that were well adapted to eating meat. This ‘killer kangaroo’ went extinct tens of thousands of years ago.”

While this footage may strike many as peculiar, Professor Tim Flannery, an expert mammalogist, says “This is unusual, I admit, but most herbivores will eat some protein if it’s available. Tree kangaroos will eat birds and even cows will chew on a bone.”

Graeme also recognizes that known herbivores are not all strict vegetarians. “White-tailed deer in the USA have been reported stealing trout from a fishing camp and removing nestlings from nests hidden in prairie grassland. Captive macropods are known to eat a wide range of foods, including chicken and lamb chops. This western grey kangaroo was simply taking advantage of an easy meal,” Graeme says.

http://www.australiangeographic.com.au/topics/wildlife/2014/02/video-kangaroo-eats-a-penguin

Posted in Biology, Food, Strange | Leave a Comment »

‘Shoe rubber’ chemical removed from subway bread found in nearly 500 common foods

Posted by Anonymous on February 28, 2014

20140227-230519.jpg
Footlong fans breathed a sigh of relief at the beginning of February, when sandwich chain Subway announced that it was removing azodicarbonamide — a chemical used in shoe rubber and yoga mats — from its bread.

Though the World Health Organization has said that the chemical is safe for human consumption, some studies have suggested it could be linked with asthma and skin and respiratory problems. And when the chemical is baked, it forms another chemical that has been linked to cancer in animal studies, CBS News pointed out. A series of popular petitions circulated by blogger Vana Hari, who runs the website FoodBabe.com, have also argued the case that its efficacy as a “bleaching agent” in bread just isn’t worth the potential health hazards.

It’s been well-established at this point that azodicarbonamide is a relatively common ingredient in processed foods. But a newly released study by the Environmental Working Group, a nonprofit, suggests that azodicarbonamide is far more common than we may have realized. EWG pored through the ingredient lists of more than 80,000 common grocery foods in an attempt to figure out which products contained the chemical. And they found it in nearly 500 items sold under 120 different brand names. …

http://www.infowars.com/shoe-rubber-chemical-removed-from-subway-bread-found-in-nearly-500-common-foods/

From Wikipedia:

As a food additive, azodicarbonamide is used as a flour bleaching agent and an improving agent. It reacts with moist flour as an oxidizing agent. The main reaction product is biurea, a derivative of urea, which is stable during baking. Secondary reaction products include semicarbazide and ethyl carbamate. The United States and Canada permit the use of azodicarbonamide at levels up to 45 ppm. In Australia and Europe the use of azodicarbonamide as a food additive is banned.

Posted in Food, Health | Leave a Comment »

Longevity Foods: The Amazing Azuki Bean

Posted by Anonymous on February 24, 2014

Jiroemon Kimura the man who lived longer than any other man in recorded history attributed his robust health to waking early in the day, watching his food portion sizes (a regular breakfast of rice porridge and miso soup), reading the newspapers and watching parliamentary debates on TV.

There may be something special about those red beans with rice.  “For his last birthday, he dined on grilled fish, steamed rice and red beans, a Japanese tradition on special occasions.” – (link)

I think Mr. Kimura was eating Sekihan (Japanese Azuki Beans & Rice). Was he growing his own food? He retired in 1962 at age 65 after 40 years as a postman and was then a farmer until age 90.

Azuki beans are a good source for a variety of minerals. They are rich in soluble fiber which lowers bad LDL cholesterol, low in calories and fat, they have healing properties for kidney, bladder and reproductive functions. The bean has diuretic effect to strengthen kidneys and may act an effective cure for urinary dysfunction and bladder infections. The presence of plant estrogens in these beans has been credited in breast cancer prevention by reducing body estrogen levels. The beans are high in protein (~25%) and easy to digest.

Azuki beans, 1 cup (230g) (cooked, boiled)
Calories: 294
Protein: 17.3g
Carbohydrate: 57g
Total Fat: 0.23g
Fiber: 16.8g
4.6 mg of Iron (~25% RDI)
119.6 mg of magnesium (~30% RDI)
1.223 g of potassium (~25 % AI)
4.0 mg of zinc (~25% RDI)
278 µg of folic acid (~70% RDI).

I’m going to try to grow some here in California. I was glad to hear that they are somewhat drought resistant.

Climatic requirements. Seeds do well during frost-free periods, with cool nights. The plant is reported to be somewhat drought resistant. Adzuki beans have similar requirements to soybeans or drybeans.

Propagation and care. Adzuki is a short-day plant that does not grow well in waterlogged soil. Information from the University of Minnesota recommends treating the seeds for fungi, insects and bacteria before planting. Adzuki beans emerge more slowly when the soil is 50 to 55�F. In Minnesota, the best planting time is between May and June. A good plant population is 105,000 plants per acre (25-35 pounds of seed). Plant seeds in rich, loamy soil, to 1 inch deep. Plants should stand 2 to 3 inches apart. Recommended row spacing varies from 12 to 18 inches, or 18 to 30 inches. Neutral to alkaline soil is required for maximum N fixation, and a medium to high soil test level of P and K should ensure adequate fertility levels and the best crop yield. Fertilize seedlings when they are 4 to 5 inches high and again when the flowers start to form pods. Moisture should be ample and at a consistent level. Uneven ripening is characteristic of adzuki beans. Expect mature pods, brownish in color, with slightly yellow and completely green pods on the same plant. Adzuki beans will fix nitrogen but require innoculation with a Rhizobium strain specific to this crop.

White mold, bacterial stem rot, and other bean diseases may affect adzuki beans. A good rotation program, furrow rather than overhead irrigation, use of disease-free seed and a spray program can help prevent these diseases. Most adzuki varieties are susceptible to a number of aphid borne viruses that attack legumes, including curly top virus.

Harvest and postharvest practices. To harvest as green beans, pick the adzuki pods when the beans are faintly outlined in the pod. Picking every 5 to 6 days is usually sufficient. In California Adzuki beans will mature in less thatn 120 days for use as dry beans.

Growers can cut and windrow adzukis in the morning to allow drydown and combine later in the day, or direct combine the beans with a grain header or row crop headers. Pods shatter very easily, especially if the harvest is delayed until late in the season or the day. To decrease losses, use slower speeds, open the concaves, and harvest only during appropriate hours. The entire plant, including dry pods, can be harvested and stacked in a dry, well-ventilated place for drying. Complete drying occurs a week or two after harvesting. After drying, shell the beans and store in refrigerated, air-tight containers.

Pest and weed problems. Adzuki beans compete poorly against weeds. Seed quality is critical to early vigor. Choose a location with light weed pressure and rotary hoe 7 to 10 days after planting. Cultivate the beans when the primary leaves are fully developed, and if necessary, 10 to 20 days later. …

https://www.rain.org/greennet/docs/exoticveggies/html/adzukibean.htm

Another important tip seems to be this: eat less!

So what does the world’s oldest man eat? The answer is not much, at least not too much. Walter Breuning, who turned 113 on Monday, eats just two meals a day and has done so for the past 35 years. “I think you should push back from the table when you’re still hungry,” Breuning said. At 5 foot 8, (“I shrunk a little,” he admitted) and 125 pounds, Breuning limits himself to a big breakfast and lunch every day and no supper. “I have weighed the same for about 35 years,” Breuning said. “Well, that’s the way it should be.”  “You get in the habit of not eating at night, and you realize how good you feel. If you could just tell people not to eat so darn much.” – link

I love food too much. Would you rather eat all you want and be happy and comfortable … and die 20 years earlier? There is no solid evidence yet in primates that reducing calories will make you live longer, but there are hints.  Azuki beans, which are low in calories, make it easier to accomplish calorie restriction with adequate nutrition (CRAN) because they give healthy levels of protein, vitamins and minerals. Do they taste good?

Posted in Food, Health, Survival | Leave a Comment »

Rat cake revolts man on his 96th birthday

Posted by Anonymous on February 24, 2014

New York grocery chain said it never had a rodent complaint before a 96-year-old Long Island man claimed he found a dead rat baked into his birthday cake.

King Kullen bakery said in a written statement this weekend that it had recalled everything from the shelves of its bakeries, which are located inside its grocery stores.

“Product has been removed from the bakery and the premises has undergone a thorough inspection,” the statement said. “There are no known safety or rodent issues in this bakery.”

But Neil Gold said there was at least one rodent issue. His aged uncle Joe allegedly got a rude surprise last week at his birthday celebration when he noted his German apple ring cake had a somewhat ratty taste to it.

“He said, ‘It doesn’t taste right,'” Gold told WABC-TV in New York. We flipped it (the cake) over and seemed to be a rat’s tail.”

The Gold family lawyer, Ed Yule, told WABC he suspected someone tampered with the cake and will turn it over to New York state officials for further investigation.

via King Kullen pulls bakery products after rat found in birthday cake – UPI.com.

Happy 96th birthday, Mr. Neil Gold. Life is like that, isn’t it? If I was the judge hearing your case, I’d say the King Kullen store, if found responsible after an investigation by the health department, owes you free groceries for  life. Then you should really get ‘em back by living to 116 like Jiroemon Kimura did! Best wishes.

 

Posted in Food, Strange | Leave a Comment »

 
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